In the present study chemical composition of four brands of gutta-percha (Autofit, Endose- quence, Wave One Gold and Dia-ProT) was analyzed for use in warm vertical condensation techniques from a qualitative point of view, using microextraction in solid-phase with sub- sequent analysis by gas chromatography cou- pled to mass spectrometry to perform such analysis and to obtain reference of the volatile organic compounds (VOCs) present in the samples. The results showed differences in the composition of the marks, with only four si- milar VOCs in all the samples. Most of the compounds found are of plant origin, but Butyl hydroxy Toluene (present in all samples) be- longs to Group 3 of the International Agency for Research on Cancer classification, in which there is no evidence of possible demonstrated carcinogenesis, but its use is being limited by several countries. The identification of VOCs has a special interest to avoid the occurrence of adverse events in endodontic treatments and should be consider by the health authori- ties when establishing controls on the com- mercialization of dental health products.