This article deals with the relationship between the creator of psychoanalysis, Sigmund Freud, and the Latvian-born Chilean professor of physiology – and endocrinologist and anthropologist – Alejandro (or Alexander) Lipschu ̈tz. Up till now, the historiography of psychoanalysis in Chile has ignored the existence of this relationship, that is to say, the fact that there exists an interesting exchange of correspondence as well as references to Lipschu ̈tz in some important works published by Freud and in Freud’s correspondence with the Hungarian psychoanalyst Sa ́ndor Ferenczi. There are also references to works on psychoanalysis carried out by Lipschu ̈tz in Chile. The Freud–Lipschu ̈tz relationship allows us to examine two interesting topics in contemporary historiographical approaches to psychoanalysis. First, it permits us to reflect on the connections that Freud and Ferenczi sought to establish between psychoanalysis and biology (endocrinology in particular) as a strategy to address criticism of the scientific foundations of psychoanalysis and, therefore, to help legitimize psychoanalysis in the field of science. Second, the relationship between Freud, working in a culturally influential city such as Vienna, and Lipschu ̈tz, working in a ‘peripheral’ country such as Chile, paves the way to reflect on the consequences of a history of psychoanalysis written from the perspective of the ‘margins’. This is a history that focuses not on regions where early industrialization and modernization processes, along with an important academic and scientific tradition, help explain the interest in and reception of psychoanalysis, but on regions where different sets of conditions have to be examined to explain appropriation and dissemination processes.